To start PowerPoint in Safe Mode, type: powerpnt.exe /safe.To start Excel in Safe Mode, type: excel.exe /safe.To start Word in Safe Mode mode, type: winword.exe /safe.To start Outlook in Safe Mode, type: outlook.exe /safe.Press simultaneously the Windows + R keys to open the 'RUN' command box and then give one of the following command according your case: Tip: If you cannot start the malfunctioning Office application normally, then start it in safe mode and then disable add-ins. (Office 2003, 2007, 2010, 2013 & 2016) How to Manage – Enable or Disable – Addins in Office Applications. In this tutorial you can find instructions to manage and disable the unnecessary plugins in Word, Excel, Outlook and PowerPoint programs to improve their performance. Although add ins are generally useful, in some cases they can cause the malfunction of a program and you have to disable them in order to regain the program's functionality. For example an 'Antivirus' add-in, for Outlook Email program, can offer antivirus protection for all received e-mails. An 'Add-in' (also known as: plugin, addin, add-on, addon, or extension) is a software component that adds a specific feature to a specific application.